[The Fish Sense Something is Amiss] Patience/Patience II Interruption.
While I understand that the Lockout at a location while fishing is to stop people from essentially using botting programs to make money with high priced fish, but the ability of the lockout to trigger while under the effect of Patience/Patience II is a bit ridiculous. The lockout effect could at least hold off until the effect of these are no longer in effect.
Both of these abilities costs the greater portion of your GP while fishing, and regardless, the simple solution to the "Fish being amiss" lockout is a quick relog, but that doesn't return my GP to me, and hinders fishing, especially when you're fishing for specific fish that are only gathered under very specific conditions (Weather/Time/Mouch/Double-Mouch), where you may spend lengthy periods of time at a fishing spot.
Anyhow, this is more of a quality of life fix more than anything, but I'm sure I'm not the only one that has suffered this circumstance either.