Game Freezes 5 min after screen blip

So for about 2 months now, I have had this issue where while playing in fullscreen, my PC will do its usual background popup notification for whatever which will "blip" the game out. By that I mean after a couple of seconds of unresponsiveness the screen goes black for one second but immediately comes back good as new. However, about 5 minutes later, regardless of what I am doing, the game will freeze. Thankfully, I have gotten this to not require a full restart of my computer, but I still have to force end task the game to fix it.

For those who will ask, "Why not switch to borderless windowed?" my answer is because I am playing on a 4K TV, so playing in fullscreen with a resolution of 2560x1440 is the best way for me to play, currently. I just did a full clean install of my graphics drivers with no luck.

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System Information
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Time of this report: 5/28/2017, 11:30:24
Machine name: G_MACHINE
Machine Id: {D480BF7A-0307-48D6-A398-A6AFF4752BD6}
Operating System: Windows 10 Home 64-bit (10.0, Build 14393) (14393.rs1_release_sec.170427-1353)
Language: English (Regional Setting: English)
System Manufacturer: ASUS
System Model: All Series
BIOS: 2501
Processor: Intel(R) Core(TM) i5-4690K CPU @ 3.50GHz (4 CPUs), ~3.5GHz
Memory: 16384MB RAM
Available OS Memory: 16324MB RAM
Page File: 4647MB used, 28060MB available
Windows Dir: C:\WINDOWS
DirectX Version: DirectX 12
DX Setup Parameters: Not found
User DPI Setting: Using System DPI
System DPI Setting: 288 DPI (300 percent)
DWM DPI Scaling: UnKnown
Miracast: Available, with HDCP
Microsoft Graphics Hybrid: Not Supported
DxDiag Version: 10.00.14393.0000 64bit Unicode