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On DF if you don't end up with a healer, floor 25 is a bit of a killer. Enemy rooms hit hard with at least 3-4 mobs. Would be ideal to do it with one considering that PotD DF doesn't always give you the ideal party setup.
Wiped twice on that floor so far with the heavy mob setup on the rooms.
I wiped on floor 35....got put to sleep then minotaur swing-ed lol a deadly combination.
its random for everyone , your 25th floor is not like the others
but i wiped twice in the 2nd set of floors 11-20
Some people in my FC went in without a healer and said it was pretty tough later on.
I went in another preformed group in my FC, as a WHM, and it's been pretty easy for us.
We had 1 wipe due to Slime's self-destruct attack which instantly killed everyone.
We also almost ran out of time before floor 30 because we were standing around and chatting a lot. At floor 27 we realized "uh oh, we only have 15 minutes left".
But other than that It's been pretty easy. I haven't had to heal much except for traps. Esuna is definitely useful.