targeting and F keys

I've been having trouble with targeting for some time now. I was in Nanway Mines yesterday (pre-patch) and was trying to target my friend to cure him. (yes, we had formed a party.) Sometimes f2 worked, and sometimes it doesn't, which is par for the course for me. But yesterday, f2 did not take the cursor to my friend; it went to a mob in the neighboring room.

Also, while soloing after the patch last night, I was sometimes able to target myself with f1 and sometimes not. F11 worked for targeting others for the most part, as did f12. (sorry, I've already forgotten which is for npc's and which for pc's.:( ) Since I didn't group with anyone, I don't know about f2.

Has anyone else had problems with f-key targeting? As a healer coming from ffxi, it is how I target party members, so it is an old habit. I will change it if I must but would rather not. Does anyone have suggestions for this?

Thank you!