Labor of Love and Final Zodiac Quest

Does Completing the Final quest for Zodiac Weapon number 1 (i135) HALT chances of completing dungeon drops for Labor of Love (for a separate Zodiac Weapon number 2 (i115)?

Going on 50 runs of AV and HM hardmode now, and as much fun as this frustration is, it really isnt. I did notice that once I turned in the final mahatma for my bow and complete that, ALL PROGRESS in Labor of Love has been halted.

Since the Relic quest strings are the same, it wouldn't surprise me if completing the bow made the game stop considering me for Labor of Love quest drop. Any chance at a confirmation this is working/working as intended?

Labor for Love, A Ponze of Flesh, Method in his Malice, and A Treasured Mother are independent from the actual Relic quest line. You can begin them again immediately after completing them, even if you don't have a single relic that then can be applied to.

If completion of a separate quest has affected any of those 4, you have indeed found a bug.