I just managed to take down Queen Bolete as 37 CON. Not terribly hard, but I'm pretty proud of it what with the MP cost on Cure spells. Siphon MP'd when it was available and used Tranquility twice (took me about 15 minutes). I definitely couldn't have done it without Sleep, that's for sure.:D
Sure, the drop has nothing to do with CON, but it was fun, nonetheless.