UI macro/action-bar lag?

I am just curious if this is a normal thing or not but I find myself having to spam each of my hotkeys numerous times before the actual action goes off. Its especially frustrating when I create a macro string for something like /ac Convalescence, /ac Second Wind. I understand I'll have to spam macros such as this one, but it isn't specific to any one action or macro.

My first thought was that my connection to the server was potentially drained, but when I pinged it, it seemed to bounce between 35 and 45. Never any higher and rarely lower. After resolving a server conflict I lowered my GFX settings to see if that would have an effect, and no change.

This isn't a game breaking issue for me, but it is slightly frustrating when I expect a response and don't get one. I find more time staring at my action bars than I do combat to ensure that my abilities are going off.

Just thought I'd see if this is an issue universal to everyone, or if its even an issue at all.