Serious answer: that one filler quest in the Ivalice raid series that has you like, wandering off to get wine for some jerk's girlfriend or whatever. Only quest in this game that's ever felt like a genuine total waste of my time, and an irritating one to boot. Could've been saved, maybe, if I had an option to pour out the wine on the obnoxious quest giver's head.
Less serious: Moogles. Banish them all.
This is hilarious to me because a lot of the people I've raided with in the past were also roleplayers. Imagine enjoying more than one thing in a video game. Inconceivable I know. :p
