Dude, didn't you quit the game?
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I think the debuff in E10S that turned into Doom if you screwed up voidgates was actually also Twice-Come Ruin, though I might be misremembering. So, yeah, I fully expect it to show up in Pandaemonium savage at some point, even if it doesn't in this specific tier.
But in both E10S and E12S, it was in response to a specific mechanic being failed; in Delubrum Reginae it was to any mechanic being failed, so functionally taking the place of vuln stacks (as used in most content) or damage down (as used in Eden savage).
Despite how impressive that group is, it does not represent the common player. When I did zodiark I marked myself and one of the tanks as we had the fight figured out. Still took 2 or 3 tries cause a few outliners were running off into bfe. They eventually snapped around and stuck to us like everyone else.
To be fair, while I understand why they went with damage downs. It felt great to give the orb mechanic in e10s the middle finger with shielding.
My policy is very simple: I heal enough that you will survive mechanic. You are free to eat vul stack as long as it doesn't kill you. If you eat more stack than normal healing would keep you up ... that's not my problem.
The only reason people greed in this game is for fflogs, not for clear. So if they greed and die, they can cry about their parse as they wait to get up, because I ain't pop them up without swift cast.
Hrm. I don't remember it doing so, but I'll be honest that I'm not absolutely certain of that. I'm mostly certain it didn't in Eden savage -- you got the damage down debuff independently of Twice-Come Ruin if you screwed up a mechanic, I seem to recall -- and I assumed they'd just literally used the same debuff. But like I said, I may be mistaken.
I am like 98% positive that Thrice-Come Ruin in Delubrum savage didn't, but maybe that was only because it didn't have a timer. (I.e., you only got to screw up twice, period, across an entire fight before it just nuked you.)