Originally Posted by
Cynfael
Yeah, that makes your experience a bit different than that of the average player. Maybe someone with similar difficulties can make suggestions as to how to improve the UI further if possible.
Although, if it helps (and if you haven't already done so), try mapping your most commonly used actions to the keyboard or mouse. I use Q, E, R, Space, Z, X, and +Shift combinations thereof to minimize the need to click on the UI. Whether that at all addresses your problem I don't know, but personally I find clicking on the UI to be a slight annoyance regardless of eyesight.