I'm going to take the extreme approach and say that almost all of the Scions will die.
On a meta level, we're supposed to be dropping the Scions and moving into a new saga of the story with new characters in 7.0. On that basis alone there's no real need to keep them alive beyond the impact of their reappearance much later down the line, yet in itself that would be lacking if they were simply still around, randomly idling in the background. And narratively it's very questionable for them to just let WoL go off on a new adventure without most of the party tagging along, unless the organization is straight-up dissolved and most of the characters gone. Moreover, I've been reconsidering some of the story recently, and I think this is something that's actually been foreshadowed. To the degree that they've actually told us the order in which they'll die.
In 4.4 and 4.5, the Scions are called away one by one by G'raha's spell. We later learn that this is happening because their fates are all closely tied to WoL, and thus his summoning is reacting to them. But what's interesting about this is the succession in which this happens - First Thancred, then Y'shtola and Urianger, then Alphinaud, then Alisaie. Obviously this can't strictly be based on physical proximity to WoL given that Thancred is seated farthest away during the meeting, and Alphinaud was an entire continent away when he was snatched. So, in my conception, they're called in this way because the spell is drawing them in accordance with the order in which their fate's entwinement with WoL is ended, IE the time of their deaths.
This would mean Thancred dies first, then Y'shtola and Urianger go out together, then Alphinaud, then Alisaie. And interestingly, this same ordering of characters is repeated, albeit in reverse, at the end of Shadowbringers 5.0. In the final confrontation with Emet-Selch, first Alisaie charges him and is wiped out, then Alphinaud is spiked, then Y'shtola and Urianger are both taken out simultaneously, then Thancred and Ryne are the last to go. Of course if we follow this notion further, Ryne has already been the first one to be effectively ejected from the narrative, so it continues that Thancred would be next, then so on down the line.
Now by that very reasoning with Ryne this doesn't necessarily mean they all die, just be effectively removed from the story somehow, which I suppose defeats the point. But in her case, there's a good in-universe reason for it, while the rest of the Scions don't really have any excuses beyond dying.
