Usually once every expansion, aside that, not much just little things you change through the course of time.
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When I started playing this game I changed all the text colours and keybindings to be the same as they were in WoW since that was what was familiar to me. The only time I make changes now is when a new expansion comes out and I need to prune or add new abilities.
Never really.
I did remove some spells like Flash since they no longer exist but other then that my hotbars been the same since 2014.
Never unless they change or remove job skills.
Once an expansion, when I get new skills.
Sometimes not really even then, just slotting new skills into blank space / removed abilities.
I guess I've changed my "main class" like 5 times over the years, so then as well.
Aaand macro'd my hunt bills to save hotbar space. Now some extra general slots I can fill with... something.
Honestly surprised how little people seem to change. My hotbars have certainly gone through some iterations.
Total fresh newbie beginner just using one, maybe two hotbars.
There was a period where I tried some focus target healing macros off on their own hotbar.
At some point I switched over to utilizing NUM pad. May have been around then that I set up a shared hotbar for some generic stuff.
Now I'm assessing buttons that should be easily within reach of my typical hand placement and upping my buttons while hopefully reducing some of the skill scatter, reorganizing a bit.
Next might be looking into setting some new Ctrl+ binds, though Idk if that works for NUM pad...
I only change them when my abilities change.
I usually only change them during the leveling process, with the skills I use the least being the ones that are the most likely the move around since they are the least likely to be bound to muscle memory. Moving around skills that are used frequently can actually be disastrous in some cases. Sometimes this is necessary though. As I gain experience with any job, I will typically notice that some skills will flow better if assigned to a different slot. When this happens, I will usually spend some time solo or on a dummy getting used to the new placement.
I've made two, maybe three major revisions to my hotbars since ARR, but hundreds of small adjustments on a per-Job basis, to the degree that I don't think my hotbars from 2021 would be recognizable as the ones from 2013, outside of maybe one or two keybinds that never change.
My sprint has been on the same button since beta and that might be the only thing.