This is what I do.. they should add sound to all the painful AOEs since I tend to dodge them much more reliably...
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Surprised nobody mentioned this yet.
Most bosses have a global cooldown of 8 seconds ish, considering every healing spell takes 3 ish to cast (and recast) move after every 2 cures and cast your cure right after the aoe hits.
what you can do, if your system (only counts for PC-player ofc) lacks a bit, is lowering the grafic as far as possible. i noticed that your character runs slower when your framerate drops. (My GPU is realy weak and a friend was faster in a straight line)
Before changing, i got killed in every movementsensitive encounter (even Titan normal *cry*) - afterwards it become kinda easy. The only exception till now is titan EX, as the usual tactic groups up direct behind him, wich leads to overlaping plums, wich absolutly kills my framerate.
but i managed to survive now, as i stand seperatet further behind. this means i have only a single plum to handle for my GPU wich worked out fine. But there it is important to watch out for the "upheaval" - you have to run into the group then. :)