Oh for sure. From that sort of perspective, it's only ever going to be a loss.
That's not the best angle to take if you really want to push things though. Think outside the box, it'll be easy enough to generate Blood Lilies during the first two boss fights. Depending on how big the trash pulls between end up, there's a very real chance that it'll be quite a significant gain to simply stock up on Lilies to drop a pair of Miseries on the trash.
Even Lilies were abusable in a similar manner in the likes of Ala Mhigo, squeezing out an extra couple of assizes on some of the particularly substantial pulls in the middle section of the run.
