At around 350 craftsmanship or so (slightly before) you should be able to 2 shot 1 star 40 crafts such as Twinthread with Careful Synth II without Ingenuity active. If you don't quite have the stats to 2 shot it, then you probably still have use for HQ mats (aka, it still matters if you're using NQ or HQ Twinthread for making stuff) and thus should probably be using Ingenuity anyways.
