we have 200 equipsets, 22 jobs. Very few people actually play all 22 at a high enough level to actually even use all of those.

Remember you can do a macro of:
/equipset
/equip
/equip
/equip
/ws or w/e <wait>
/equipset

you don't need a bunch of different equipsets for a bunch of different actions, typically you can get away with one equipset for ALL your WSs, maybe two equipsets.