Do the modifiers do nothing at all, or the keys are not changing with them either?

For example by default, just now, with 'Compact 2' I have the equipment window opening with 'ctrl+e' and if I change it to confirm, it does seem to work.

As a bonus, if someone ever wondered what it would be like to have slippery ground mechanics in this game, I imagine it would be something like what happens when running and changing directions while holding down the shift key (while using the third-person camera view).