When I started I asked a GM why i couldn't have Macro 1 Turn on Macro 2 and the GM told me it prevents automation. The example they gave is Macro 1 having 3 enhancing spells, and 2 having 2 spells and refresh and having #1 start #2 and #2 start #1 so you could go AFK and cap enhancing magic. So long as there is no way for this situation to occur I see no reason why you couldn't allow a gear set as a single macro line in some way.