I've played with /sam when I was trying to get Rune leveled when it came out to take Gs to its new cap and made use of Seigan + Eye alot in worm parties. Used /pld until lv 30 and briefly again while farming leach's in the sewers.
I played with /whm when it came to fighting with Amarok (to remove paralyse or poison if it did land). Its ok, I get access to banish I & II, Dia I & II, banishaga I & II, daiaga, haste, reraise, cure 1~4, Divine seal for emergencies, Repose, every stat cure and bar-aga up to lv 49 on whm. Rune doesn't have native dark, enfeebling, or elemental magic skills so I keep my spell list limited to mostly enhancing and Divine. For now I've only been using Run/whm to farm reives in some gates, some Abyssea NM's, and to help skill my divine magics. I have not tried it but how practical would Run/whm be as a sidearm for a pld tank? Not as much dmg so it won't easily steal hate. It can resist and evade most atacks and apply some first aid to pld.
I don't think the adjustment for Last Resort was out by the time most folks was leveling rune. While I recently toyed with getting the dmg boost and haste from /drk, I'd need a healer near by for when I would take to much damage. In aby farming /drk I'm double stacking regen atmas but that's in Abyssea.
If anything I still need to get more accessories to enhance buffs and that Flume belt. I know some folks went /nin when it came to farming in thf-ish gear macros but I have no idea what the output on that would be.

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