My first choice is that the targeting priority could be customizable somehow, or the addition of separate commands for specifically targeting NPCs-only or monsters-only. Things a little bit beyond just "Mister Eff-Eight likes ???'s better now."

If that's not possible, I'd rather it just be left alone entirely. I've gotten a pretty good feel for my F8 key's deviant predilections over the past decade and I don't want it to suddenly drop those and develop new ones.