I really find using the numpad and arrow keys both with the same hand very intuitive, so I use the full keyboard mode. Generally, my thumb controls the camera, back and target switching, index for left and auto run, middle for forward and heal/ lock on, Ring for right, menu, and chat log, and my pinky for enter. Because my hands are massive, this means I can use my left hand for macros or perhaps drinking while my right hand deals with moving. The only beef I have with it is there's no way to go back in menus outside of Escape, meaning I gotta put down my beer to get out of my item screens or cancel dialogue. I wish that numpad delete did that.