Easier said than done, you don't always realize that you're under the effect in a pinch. I would go so far as to compromise for having a 1 min timmer down on using another item if one was paralyzed over losing it completely. I've never lost a brew or anything important to paralysis, just think it doesn't make an ounce of sense that the item vanishes. It doesn't add a challenge, if you want a challenge set that timmer to 5 mins on a paralyzed item, it's more annoying than anything else.