Many (most) alchemy guild point items require base items which are high-level synths from other crafts and are rarely sold.
(e.g. Venom Kris).
I feel the degree to which this is true is unfair compared to other crafts.
Please do one of two things:
1.) Remove these GP items for other items which can be synthesized from raw materials.
or
2.) Make these base weapons (darksteel kris etc.) available from NPCs somewhere.
Seeing as most of these mid-level base weapons are sold virtually never, I really don't think making them available from NPCs is going to hurt anyone's wallet.